An Unbiased View of modafinil dosage
Warfarin's fewer powerful R-enantiomer is metabolized in part by CYP3A4 (and also CYP1A2 and CYP2C19). Keep an eye on INR much more frequently if coadministered with inhibitors of these isoenzymes and regulate warfarin dose if wanted.
posaconazole will improve the stage or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
modafinil will decrease the level or effect of iobenguane I 131 by Other (see remark). Prevent or Use Alternate Drug. Determined by the mechanism of motion of iobenguane, medicine that lessen catecholamine uptake or that deplete catecholamine merchants might interfere with iobenguane uptake into cells, and thus, lower iobenguane efficacy.
Provigil could potentially cause skin reactions Which may be severe sufficient to want procedure inside of a healthcare facility. Stop getting this medication and acquire unexpected emergency health care support Should you have:
Efficacy and protection of adjunctive modafinil treatment on residual extreme daytime sleepiness among the nasal constant optimistic airway pressure-addressed japanese clients with obstructive rest apnea syndrome: a double-blind placebo-managed examine.[J Clin Sleep Med. 2013]
Influence of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib has not been analyzed.
rifabutin will minimize the extent or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
People must be advised to talk to their Health care company quickly should they encounter a rash or any allergic response, depression, panic, or indications of psychosis or mania.
apalutamide will lessen the extent or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine which have been CYP3A4 substrates may result in lessen publicity to those drugs.
stiripentol will improve the level or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Carefully. Think about cutting down the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.
Watch Closely (1)voriconazole will boost the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
No distinct antidote exists for that harmful effects of a PROVIGIL overdose. This sort of overdoses really should be managed with generally supportive treatment, such as cardiovascular monitoring.
efavirenz will decrease the level or effect more info of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Minimal (one)modafinil will improve the degree or effect of lansoprazole by influencing hepatic enzyme CYP2C19 metabolism. Insignificant/Significance Not known. Internet effect on pantoprazole steps unidentified because of opposing consequences of CYP450 enzymes; keep an eye on